Selected Publications

Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 2017 May 30;114(22):5731-5736.

Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M. Peripherally administered orexin improves survival of mice with endotoxin shock. Elife. 2016 Dec 30;5. pii: e21055.

Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. Nov 17;539(7629):378-383.

Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M. Identification of mutations through dominant screening for obesity using C57BL/6 substrains. Sci Rep. 2016 Sep 2;6:32453.

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M. Mesolimbic neuropeptide W coordinates stress responses under novel environments. Proc Natl Acad Sci U S A. 2016 May 24;113(21):6023-8.

Lee, I.T., Chang, A.S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J.E., Takahashi, J.S., Yanagisawa, M. Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. Neuron. 2015 Mar 4; 85 (5): 1086-102.

Ikeda, Y., Kumagai, H., Skach, A., Sato, M., Yanagisawa, M. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXR7 signaling alters emotional behavior. Cell. 2013 Dec 5; 155 (6): 1323-36.

Suzuki, A, Sinton CM, Greene RW, & Yanagisawa M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. Proc Natl Acad Sci U S A. 2013 Jun 18; 110 (25): 10288-10293.

Chang, I., Bramall, A.N., Baynash, A.G., Rattner, A., Rakheja, D., Post, M., Joza, S., McKerlie, C., Stewart, D.J., McInnes, R.R., & Yanagisawa, M. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 2013 Jun 3; 123 (6): 2643-53.

Funato, H., Sato, M., Sinton, C.M., Gautron, L., Williams, S.C., Skach, A., Elmquist, J.K., Skoultchi, A.I., & Yanagisawa, M. Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep. Proc Natl Acad Sci U S A. 2010 Oct 19; 107 (42): 18155-60.

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima. N., Kunita, S., Takahashi, S., Yagami, K., Kilduff, T.S., Bettler, B., Yanagisawa, M. & Sakurai, T. Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A. 2009 Mar 17; 106 (11): 4459-64.

Irukayama-Tomobe, Y., Tanaka, H., Yokomizo, T., Yanagisawa, M. & Sakurai, T. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 2009 Mar 10; 106 (10): 3930-4.

Funato, H., Tsai, A.L., Willie, J.T., Kisanuki Y., Williams, S.C., Sakurai, T., & Yanagisawa, M. Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab. 2009 Jan 7; 9 (1): 64-76.

Mieda, M., Williams, S.C., Richardson, J.A., Tanaka, K. & Yanagisawa, M. The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc Natl Acad Sci U S A. 2006 Aug 8; 103 (32): 12150–5.

Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S.C., Iguchi, H., Kawasawa, Y.I., Ikeda, Y., Sakakibara, I. Ohno, K. Ioka, R.X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T. Ohuchi, T., Yanagisawa, M. & Sakai, J. A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci U S A. 2006 May 9; 103 (19): 7438-43.

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M. Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron. 2005 Apr 21: 46 (2): 297–308.

Mieda, M., Williams, S.C., Sinton, C.M., Richardson, J.A., Sakurai, T. & Yanagisawa, M. Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci. 2004 Nov 17; 24 (46): 10493-501.

Mieda, M., Willie, J.T., Hara, J., Sinton, C.M., Sakurai, T. & Yanagisawa, M. Orexin peptides prevent cataplexy and improve wakefulness in orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A. 2004 Mar 30; 101 (13): 4649-54.

Beuckmann, C.T., Sinton, C.M., Williams, S.C., Richardson, J.A. Hammer, R.E., Sakurai, T. & Yanagisawa, M. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J Neurosci. 2004 May 5; 24 (18): 4469-77.

Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M.A., Motoike, T., Kedzierski, R.M., & Yanagisawa, M. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 2004 Jan 27; 101 (4): 1045-50.

Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., Lee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E. & Yanagisawa, M. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 2003 Jun 5; 38 (5): 715-30.

Yamanaka, A., Beuckmann, C.T., Willie, J.T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K., Sugiyama, F., Goto, K., Yanagisawa, M. & Sakurai, T. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron. 2003 Jun 5; 38 (5): 701-13.

Tanaka, H., Yoshida, T., Miyamoto, N., Motoike, T., Kurosu, H., Shibata, K., Yamanaka, A., Williams, S.C., Richardson, J.A., Tsujino, N., Garry, M.G., Lerner, M.R., King, D.S., O’Dowd, B.F., Sakurai, T. & Yanagisawa, M. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc Natl Acad Sci U S A. 2003 May 13; 100 (10): 6251-6.

Gariepy, C. G., Ohuchi, T., Williams, S. C., Richardson, J. A. & Yanagisawa, M. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. J Clin Invest. 2000 Apr; 105 (7): 925-333.

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 1999 Aug 20; 98 (4): 437-51.

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W.-S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & Yanagisawa, M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998 Feb 20; 92 (4): 573-85.

Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J. A., Emoto, N., Hammer, R. E. & Yanagisawa, M. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell. 1994 Dec 30; 79 (7): 1277-85.

Hosoda, K., Hammer, R. E., Richardson, J. A., Greenstein Baynash, A., Cheung, J. C., Giaid, A. & Yanagisawa, M. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell. 1994 Dec 30; 79 (7): 1267-76.

Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D. & Yanagisawa, M. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell. 1994 Aug 12; 78 (3): 473-85.

Sakurai, T., Yanagisawa, M., Takuwa, Y., Miyazaki, H., Kimura, S., Goto, K. & Masaki, T. Cloning of a cDNA encoding a non-isopeptide selective subtype of the endothelin receptor. Nature. 1990 Dec 20-27; 348 (6303): 732-5.

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K. & Masaki, T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 1988 Mar 31; 332 (6163): 411-5.