Selected Publications

Komiya H, Miyoshi C, Iwasaki K, Hotta-Hirashima N, Ikkyu A, Kanno S, Honda T, Gosho M, Hamada H, Satoh T, Fukamizu A, Funato H, Yanagisawa M. Sleep/wakefulness behaviors in mice during pregnancy and pregnancy-associated hypertensive mice. SLEEP. 41(3):  2018  doi: 10.1093/sleep/zsx209.

Irukayama-Tomobe Y, Ogawa Y, Tominaga H, Ishikawa Y, Hosokawa N, Ambai S, Kawabe Y, Uchida S, Nakajima R, Saitoh T, Kanda T, Vogt K, Sakurai T, Nagase H, Yanagisawa M. Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc Natl Acad Sci U S A. 114(22):5731-5736, 2017

Ogawa Y, Irukayama-Tomobe Y, Murakoshi N, Kiyama M, Ishikawa Y, Hosokawa N, Tominaga H, Uchida S, Kimura S, Kanuka M, Morita M, Hamada M, Takahashi S, Hayashi Y, Yanagisawa M. Peripherally administered orexin improves survival of mice with endotoxin shock. Elife. 5: e21055, 2016

Funato H, Miyoshi C, Fujiyama T, Kanda T, Sato M, Wang Z, Ma J, Nakane S, Tomita J, Ikkyu A, Kakizaki M, Hotta-Hirashima N, Kanno S, Komiya H, Asano F, Honda T, Kim SJ, Harano K, Muramoto H, Yonezawa T, Mizuno S, Miyazaki S, Connor L, Kumar V, Miura I, Suzuki T, Watanabe A, Abe M, Sugiyama F, Takahashi S, Sakimura K, Hayashi Y, Liu Q, Kume K, Wakana S, Takahashi JS, Yanagisawa M. Forward-genetics analysis of sleep in randomly mutagenized mice. Nature. 539(7629):378-383, 2016

Hossain MS, Asano F, Fujiyama T, Miyoshi C, Sato M, Ikkyu A, Kanno S, Hotta N, Kakizaki M, Honda T, Kim SJ, Komiya H, Miura I, Suzuki T, Kobayashi K, Kaneda H, Kumar V, Takahashi JS, Wakana S, Funato H, Yanagisawa M. Identification of mutations through dominant screening for obesity using C57BL/6 substrains. Sci Rep. 6:32453, 2016

Motoike T, Long JM, Tanaka H, Sinton CM, Skach A, Williams SC, Hammer RE, Sakurai T, Yanagisawa M. Mesolimbic neuropeptide W coordinates stress responses under novel environments. Proc Natl Acad Sci U S A. 113(21):6023-6028, 2016

Lee, I.T., Chang, A.S., Manandhar, M., Shan, Y., Fan, J., Izumo, M., Ikeda, Y., Motoike, T., Dixon, S., Seinfeld, J.E., Takahashi, J.S., Yanagisawa, M. Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms. Neuron. 85 (5): 1086-1102, 2015

Ikeda, Y., Kumagai, H., Skach, A., Sato, M., Yanagisawa, M. Modulation of circadian glucocorticoid oscillation via adrenal opioid-CXR7 signaling alters emotional behavior. Cell. 155 (6): 1323-1336, 2013

Suzuki, A, Sinton CM, Greene RW, & Yanagisawa M. Behavioral and biochemical dissociation of arousal and homeostatic sleep need influenced by prior wakeful experience in mice. Proc Natl Acad Sci U S A. 110 (25): 10288-10293, 2013

Chang, I., Bramall, A.N., Baynash, A.G., Rattner, A., Rakheja, D., Post, M., Joza, S., McKerlie, C., Stewart, D.J., McInnes, R.R., & Yanagisawa, M. Endothelin-2 deficiency causes growth retardation, hypothermia, and emphysema in mice. J Clin Invest. 123 (6): 2643-2653, 2013

Funato, H., Sato, M., Sinton, C.M., Gautron, L., Williams, S.C., Skach, A., Elmquist, J.K., Skoultchi, A.I., & Yanagisawa, M. Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep. Proc Natl Acad Sci U S A. 107 (42): 18155-18160, 2010

Matsuki, T., Nomiyama, M., Takahira, H., Hirashima. N., Kunita, S., Takahashi, S., Yagami, K., Kilduff, T.S., Bettler, B., Yanagisawa, M. & Sakurai, T. Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture. Proc Natl Acad Sci U S A. 106 (11): 4459-4464, 2009

Irukayama-Tomobe, Y., Tanaka, H., Yokomizo, T., Yanagisawa, M. & Sakurai, T. Aromatic D-amino acids act as chemoattractant factors for human leukocytes through a G protein-coupled receptor, GPR109B. Proc Natl Acad Sci U S A. 106 (10): 3930-3934, 2009

Funato, H., Tsai, A.L., Willie, J.T., Kisanuki Y., Williams, S.C., Sakurai, T., & Yanagisawa, M. Enhanced orexin receptor-2 signaling prevents diet-induced obesity and improves leptin sensitivity. Cell Metab. 9 (1): 64-76, 2009

Mieda, M., Williams, S.C., Richardson, J.A., Tanaka, K. & Yanagisawa, M. The dorsomedial hypothalamic nucleus as a putative food-entrainable circadian pacemaker. Proc Natl Acad Sci U S A. 103 (32): 12150–12155, 2006

Takayasu, S., Sakurai, T., Iwasaki, S., Teranishi, H., Yamanaka, A., Williams, S.C., Iguchi, H., Kawasawa, Y.I., Ikeda, Y., Sakakibara, I. Ohno, K. Ioka, R.X., Murakami, S., Dohmae, N., Xie, J., Suda, T., Motoike, T. Ohuchi, T., Yanagisawa, M. & Sakai, J. A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice. Proc Natl Acad Sci U S A. 103 (19): 7438-7443, 2006

Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., Kageyama, H., Kunita, S., Takahashi, S., Goto, K., Koyama, Y., Shioda, S. & Yanagisawa, M. Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron. 46 (2): 297–308, 2005

Mieda, M., Williams, S.C., Sinton, C.M., Richardson, J.A., Sakurai, T. & Yanagisawa, M. Orexin neurons function in an efferent pathway of a food-entrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J Neurosci. 24 (46): 10493-10501, 2004

Mieda, M., Willie, J.T., Hara, J., Sinton, C.M., Sakurai, T. & Yanagisawa, M. Orexin peptides prevent cataplexy and improve wakefulness in orexin neuron-ablated model of narcolepsy in mice. Proc Natl Acad Sci U S A. 101 (13): 4649-4654, 2004

Beuckmann, C.T., Sinton, C.M., Williams, S.C., Richardson, J.A. Hammer, R.E., Sakurai, T. & Yanagisawa, M. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. J Neurosci. 24 (18): 4469-4477, 2004

Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M.A., Motoike, T., Kedzierski, R.M., & Yanagisawa, M. Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proc Natl Acad Sci U S A. 101 (4): 1045-1050, 2004

Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., Lee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E. & Yanagisawa, M. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 38 (5): 715-730, 2003

Yamanaka, A., Beuckmann, C.T., Willie, J.T., Hara, J., Tsujino, N., Mieda, M., Tominaga, M., Yagami, K., Sugiyama, F., Goto, K., Yanagisawa, M. & Sakurai, T. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron. 38 (5): 701-713, 2003

Tanaka, H., Yoshida, T., Miyamoto, N., Motoike, T., Kurosu, H., Shibata, K., Yamanaka, A., Williams, S.C., Richardson, J.A., Tsujino, N., Garry, M.G., Lerner, M.R., King, D.S., O’Dowd, B.F., Sakurai, T. & Yanagisawa, M. Characterization of a family of endogenous neuropeptide ligands for the G protein-coupled receptors GPR7 and GPR8. Proc Natl Acad Sci U S A. 100 (10): 6251-6256, 2003

Gariepy, C. G., Ohuchi, T., Williams, S. C., Richardson, J. A. & Yanagisawa, M. Salt-sensitive hypertension in endothelin-B receptor-deficient rats. J Clin Invest. 105 (7): 925-933, 2000

Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., Richardson, J. A., Williams, S. C., Xiong, Y., Kisanuki, Y., Fitch, T. E., Nakazato, M., Hammer, R. E., Saper, C. B. & Yanagisawa, M. Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell. 98 (4): 437-451, 1999

Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., Williams, S. C., Richardson, J. A., Kozlowski, G. P., Wilson, S., Arch, J. R. S., Buckingham, R. E., Haynes, A. C., Carr, S. A., Annan, R. S., McNulty, D. E., Liu, W.-S., Terrett, J. A., Elshourbagy, N. A., Bergsma, D. J. & Yanagisawa, M. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 92 (4): 573-585, 1998

Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J. A., Emoto, N., Hammer, R. E. & Yanagisawa, M. Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons. Cell. 79 (7): 1277-1285, 1994

Hosoda, K., Hammer, R. E., Richardson, J. A., Greenstein Baynash, A., Cheung, J. C., Giaid, A. & Yanagisawa, M. Targeted and natural (piebald-lethal) mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice. Cell. 79 (7): 1267-1276, 1994

Xu, D., Emoto, N., Giaid, A., Slaughter, C., Kaw, S., deWit, D. & Yanagisawa, M. ECE-1: a membrane-bound metalloprotease that catalyzes the proteolytic activation of big endothelin-1. Cell. 78 (3): 473-485, 1994

Sakurai, T., Yanagisawa, M., Takuwa, Y., Miyazaki, H., Kimura, S., Goto, K. & Masaki, T. Cloning of a cDNA encoding a non-isopeptide selective subtype of the endothelin receptor. Nature. 348 (6303): 732-735, 1990

Yanagisawa, M., Kurihara, H., Kimura, S., Tomobe, Y., Kobayashi, M., Mitsui, Y., Yazaki, Y., Goto, K. & Masaki, T. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature. 332 (6163): 411-415, 1988